13. Allen Duong

Donor neutrophils and B cells in EVLP perfusate are associated with severe primary graft dysfunction.

3 Comments

  • Adele Coriati says:

    Very nice work! What clinical or demographic factors (age, sex, health complications) do you suggest might explain the differential differences in donor immune cell populations between PGD0/1 and PGD3?

    • Allen Duong says:

      Hello Dr. Coriati! Thank you for your kind words and your question.
      There are a diverse number of factors that can impact the donor immune cell populations, particularly mode of donor death (particularly donation after circulatory death due to higher warm ischemic timer), smoking history, cause of death (particularly brain death which can cause a systemic inflammatory response) or if infection was observed. All of these can cause an intial inflammatory response in the lung, which would could account for higher donor immune cells. However, that in this study, donor characteristics between the PGD0/1 and PGD3 group were compared, and there did not appear to be any significant differences in age, sex, mode of donor death, smoking status, cause of death or infection. So currently we are not sure if there is a single clinical or demographic factor that can easily explain the differences in donor immune cell populations, but we are actively looking into this.

  • Richard Leung says:

    Is there any difference between cellular vs acellular perfusate?

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