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Non-HLA Antibodies In Serum Prior To The Onset Of Chronic Lung Allograft Dysfunction.
Great work Ambily! What is the significance of an increase in anti-CCSP IgM and anti-histone antibodies in patients with CLAD and why choose those two in particular? How do you intend to further validate this result?
Thank you Zayed.
Anti-CCSP IgM and anti-histone antibodies were the main to 2 antibody reactivity to lung specific antigens we observed in our study related to CLAD development.
In a prior study by Dr. Levy et al in 2019 , CCSP levels in BAL were shown to be lower in patients who developed CLAD. Also, animal studies showed that acute epithelial injury mediated by the ablation of club cells is sufficient to cause bronchiolitis obliterans. Hence, it is possible that an increase in
anti CCSP reactivity in the serum before the onset of CLAD, may lead to a decrease in CCSPs, and may contribute to the pathogenesis of CLAD.
The role of anti-histone antibodies in CLAD is unclear at present. But it may have a role in increased humoral response after lung transplantation.Anti-histone antibodies have been observed in a number of autoimmune diseases. Inflammatory lung diseases are characterized by increased expression of multiple inflammatory genes . And such gene expression is regulated by the acetylation of histones. It is possible that anti-histone antibodies may have a role in increased humoral response after lung transplantation.
Yes, we are planning to further validate our findings in a larger cohort in the immediate future.
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